Clinical risk measurement should rest on evidence that can withstand clinical, scientific, and operational scrutiny.The research foundation for AE Outcomes

What AE Outcomes are

AE Outcomes are clinically validated adverse event outcomes, generated by Pascal's proprietary technology from real-time electronic health record and health information technology data. The term describes the outcome signal at the center of Pascal's approach to clinical risk.

Two forms of validation

Peer-reviewed published evidence. Peer-reviewed and U.S. government evidence supports the evidence-based clinical methodology Pascal uses. Pascal's own approach to real-time, electronic health record-based safety surveillance is published in Health Affairs: Classen D, Li M, Miller S, Ladner D, "An Electronic Health Record-Based Real-Time Analytics Program For Patient Safety Surveillance And Improvement," Health Affairs 2018;37(11):1805-1812. The wider evidence base for trigger-based adverse event detection includes Bates DW, Levine DM, Salmasian H, et al., "The Safety of Inpatient Health Care," New England Journal of Medicine 2023;388:142-153, which identified at least one adverse event in 23.6 percent of admissions across eleven Massachusetts hospitals.

Real-world evidence. The U.S. Department of Health and Human Services Office of Inspector General has applied trigger-based adverse event detection across successive national studies of Medicare beneficiaries, including "Adverse Events in Hospitals: A Quarter of Medicare Patients Experienced Harm in October 2018" (OEI-06-18-00400). In Massachusetts, the Betsy Lehman Center contracted with Pascal Metrics for a first-in-nation pilot of automated adverse event monitoring across a group of acute care hospitals.